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The use of the chemical modification of proteins has evolved over the past 80 years, benefiting from advances in analytical, physical, and organic chemistry. Over the past 30 years, the use of chemical reagents to modify proteins has been crucial in determining the function and structure of purified proteins. This groundbreaking work is part of the foundation of emerging disciplines of proteomics, chemical biology, structure biology, and chemical proteomics.

Chemical Reagents for Protein Modification, Fourth Edition provides a comprehensive review of reagents used for the chemical modification of proteins, representing a major revision of the work presented in previous editions. The completely updated Fourth Edition is substantially larger and includes five new chapters:

• Alkylating Agents
• Acylating Agents
• Nitration and Nitrosylation
• Oxidation
• Modification of Proteins with Reducing Agents

There is greatly increased coverage of the chemical modification of cysteine, which is critical for bioconjugate synthesis. The chapter on reduction also provides information necessary for bioconjugate synthesis as well as for the processing of inclusion bodies. The book places emphasis on conditions that affect the specificity of the chemical modification of proteins, such as solvent and temperature. The format has been markedly revised, presenting information based on the chemical nature of the modifying material and on the amino acid residue modified. This new version has increased significance to biopharmaceuticals. Much of the information is in tabular form, which enables the rapid location of cited material.

• Sales Rank: #2353476 in Books
• Published on: 2014-07-22
• Original language: English
• Number of items: 1
• Dimensions: 10.75" h x 7.50" w x 1.50" l, 3.17 pounds
• Binding: Hardcover
• 684 pages

About the Author

Roger L. Lundblad is a native of San Francisco, California. He received his undergraduate education at Pacific Lutheran University and his PhD in biochemistry from the University of Washington. After his postdoctoral work in the laboratories of Stanford Moore and William Stein at The Rockefeller University, he joined the faculty of the University of North Carolina at Chapel Hill. He then joined the Hyland Division of Baxter Healthcare in 1990. Currently, Dr. Lundblad works as an independent consultant at Chapel Hill, North Carolina, and writes on biotechnological issues. He is an adjunct professor of pathology at the University of North Carolina at Chapel Hill.

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• Published on: 2004
• Binding: Unknown Binding

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• Sales Rank: #943194 in Books
• Brand: Brand: Melvin Leigh, Publishers
• Published on: 2009
• Number of items: 1
• Binding: Paperback

Features

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Jan Rijkhoff investigates noun phrases--linguistic constructions with the noun as central element--in a representative sample of the world's 6000 languages and proposes a semantic model to describe their underlying structure. Assuming no knowledge of any formal or functional theory of grammar, he shows that the noun phrase word order patterns of any language can be derived from three universal ordering principles and furthermore that these principles are elaborations of a general ordering strategy, by which elements that belong together semantically tend to occur together syntactically.

• Sales Rank: #391249 in Books
• Published on: 2004-03-11
• Original language: English
• Number of items: 1
• Dimensions: 6.10" h x 1.00" w x 9.20" l, 1.35 pounds
• Binding: Paperback
• 440 pages

Review
Rijkhoff's book is an in-depth typological investigation of the syntax and semantics of the noun phrase in the functional grammar framework. Language

About the Author
Jan Rijkhoff is an Associate Professor in the Department of Linguistics, University of Aarhus, Denmark. Upon gaining his Ph.D. from the University of Amsterdam (1992), he was appointed as a senior researcher at the same institution before going on to become Humboldt Research Fellow at the University of Konstanz in Germany (1995). From 1990-5, Professor Rijkhoff was also a core member of Theme Group II (Constituent Order) in the European Science Foundation's 'Program in Language Typology "Eurotyp"'.

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